Name
ETHOSUXIMIDE
Mode of Action
IT IS AN OXAZOLIDINEDIONE VARIENT ; ITS PHARMACOLOGICAL PROFILE IS SIMILAR TO TRIMETHADIONE, THE PROMINENT ACTION BEING ANTAGONISM OF PENTYLENETETRAZOL. IT HAS NO EFFECT ON KINDING. DRUGS ACTION IS EXERTED ON THALAMO-CORTICAL SYSTEM WHICH RAISES SEIZURE THRESHOLD, BUT DOSE NOT MODIFY MAXIMAL ELECTROSHOCK. ETHOSUXIMIDE SUPPRESSES THE PAROXYSMAL THREE CYCLE PER SECOND SPIKE AND WAVE ACTIVITY ASSOCIATED WITH LAPSES OF CONSCIOUSNESS WHICH IS COMMON IN ABSENCE (PETIT MAL) SEIZURES. THE FREQUENCY OF EPILEPTIFORM ATTACKS IS REDUCED, APPARENTLY BY DEPRESSION OF THE MOTOR CORTEX AND ELEVATION OF THE THRESHOLD OF THE CENTRAL NERVOUS SYSTEM TO CONVULSIVE STIMULI.
Dosage
ADULT :- 500 MG SLOWLY INCREASED TO MAX . 1.5 GM/DAY OR 20-30 MG/KG/DAY. CHILDREN :- 20-30 MG/KG/DAY DIVIDED EVERY 12 HOURS.
Drug Group
[ANTIEPILEPTIC] , [OXAZOLIDINEDIONE]
Cross Reaction
CARBAMAZEPINE, PHENOBARBITONE, INCREASES CLEARANCE. PHENYTOIN, SODIUM VALPROATE, ISONIAZID MAY ALTER THE LEVELS OF ETHOSUXIMIDE IN THE BLOOD. LONG TERM THERAPY ASSOCIATED WITH FALL IN PLASMA PYRIDOXAL PHOSPHATE LEVEL.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph