CYTOTOXIC-INDUCED NEUTROPENIA, PREFERABLY BY SUBCUTANEOUS INJECTION OR BY INTRAVENOUS INFUSION (OVER 30 MINUTES), ADULT AND CHILD, 500 000 UNITS/KG DAILY STARTED AT LEAST 24 HOURS AFTER CYTOTOXIC CHEMOTHERAPY, CONTINUED UNTIL NEUTROPHIL COUNT IN NORMAL RANGE, USUALLY FOR UP TO 14 DAYS (UP TO 38 DAYS IN ACUTE MYELOID LEUKAEMIA)
MYELOABLATIVE THERAPY FOLLOWED BY BONE-MARROW TRANSPLANTATION, BY INTRAVENOUS INFUSION OVER 30 MINUTES OR OVER 24 HOURS OR BY SUBCUTANEOUS INFUSION OVER 24 HOURS, 1 MILLION UNITS/KG DAILY, STARTED AT LEAST 24 HOURS FOLLOWING CYTOTOXIC CHEMOTHERAPY (AND WITHIN 24 HOURS OF BONE-MARROW INFUSION), THEN ADJUSTED ACCORDING TO NEUTROPHIL COUNT (CONSULT PRODUCT LITERATURE)
MOBILISATION OF PERIPHERAL BLOOD PROGENITOR CELLS FOR AUTOLOGOUS INFUSION, USED ALONE, BY SUBCUTANEOUS INJECTION OR BY SUBCUTANEOUS INFUSION OVER 24 HOURS, 1 MILLION UNITS/KG DAILY FOR 5-7 DAYS; USED FOLLOWING ADJUNCTIVE MYELOSUPPRESSIVE CHEMOTHERAPY (TO IMPROVE YIELD), BY SUBCUTANEOUS INJECTION, 500 000 UNITS/KG DAILY, STARTED THE DAY AFTER COMPLETING CHEMOTHERAPY AND CONTINUED UNTIL NEUTROPHIL COUNT IN NORMAL RANGE; FOR TIMING OF LEUCOPHERESIS CONSULT PRODUCT LITERATURE
MOBILISATION OF PERIPHERAL BLOOD PROGENITOR CELLS IN NORMAL DONORS FOR ALLOGENEIC INFUSION, BY SUBCUTANEOUS INJECTION, ADULT UNDER 60 YEARS AND ADOLESCENT OVER 16 YEARS, 1 MILLION UNITS/KG DAILY FOR 4-5 DAYS; FOR TIMING OF LEUCOPHERESIS CONSULT PRODUCT LITERATURE
SEVERE CHRONIC NEUTROPENIA, BY SUBCUTANEOUS INJECTION, ADULT AND CHILD, IN SEVERE CONGENITAL NEUTROPENIA, INITIALLY 1.2 MILLION UNITS/KG DAILY IN SINGLE OR DIVIDED DOSES (INITIALLY 500 000 UNITS/KG DAILY IN IDIOPATHIC OR CYCLIC NEUTROPENIA), ADJUSTED ACCORDING TO RESPONSE (CONSULT PRODUCT LITERATURE)
PERSISTENT NEUTROPENIA IN HIV INFECTION, BY SUBCUTANEOUS INJECTION, INITIALLY 100 000 UNITS/KG DAILY, INCREASED AS NECESSARY UNTIL NEUTROPHIL COUNT IN NORMAL RANGE (USUAL MAX. 400 000 UNITS/KG DAILY), THEN ADJUSTED TO MAINTAIN NEUTROPHIL COUNT IN NORMAL RANGE (CONSULT PRODUCT LITERATURE)