THE USUAL DOSE :- I.V. INJ :- 8 TO 12 GM PER SQR METER BODY SURFACE DIVIDED OVER 3-5 DAYS. MAXIMUM 10 GM. COURSES MAY BE REPEATED AT INTERVALS OF 2-4 WEEKS, DEPENDING ON THE BLOOD COUNT. A TOTAL DOSE OF 6 G/M2 DIVIDED OVER 5 DAYS, REPEATED EVERY 3 WEEKS; AND DOSES OF 5 TO 6 G/M2, TO A MAXIMUM OF 10 G, GIVEN AS A SINGLE 24-HOUR INFUSION, REPEATED AT 3 TO 4 WEEK INTERVALS. THE INTERVAL BETWEEN COURSES ALSO DEPENDS ON THE BLOOD COUNT