Name
LEUCOVORIN CALCIUM
Mode of Action
IT IS PRINCIPALLY USED AS ANTIDOT TO FOLIC ACID ANTAGONISTS LIKE METHOTRAXATE. IT DOES NOT BLOCK THE ANTIMICROBIAL ACTION OF FOLATE ANTAGONISTS LIKE TRIMETHOPRIM AND PYRIMETHAMINE BUT MAY REDUCE THEIR HAEMATOLOGICAL TOXICITY.
Dosage
CAN BE GIVEN ORALLY, I.M. OR BY I.V. ROUTE. IT CAN BE GIVEN BY I.V. INFUSION IN A DOSE EQUIVALENT TO 75 MG OF FOLINIC ACID WITHIN 12 HOURS. FOLLOWED BY 12 MG I.M. EVERY 6 HOURS FOR 4 DOSES. FOR DETAILS SEE LIT.
Drug Group
[FOLIC ACID DERIVATIVE] , [ANTIDOT TO FOLIC ACID ANTAGONISTS]
Cross Reaction
LEUCOVORIN MAY ENHANCE THE TOXICITY AND ANTINEOPLASTIC ACTIVITY OF 5-FLUOROURACIL. REDUCES METHOTREXATE TOXICITY. PHENOBARBITONE, PHENYTOIN, PRIMIDONE COUNTERACTS THE ANTIEPILEPTIC EFFECTS.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph