LEUPROLIDE ACETATE IS A SYNTHETIC FORM OF HYPOTHALAMIC GONADOTROPHIN-RELEASING HORMONE, STIMULATES THE SYNTHESIS AND RELEASE OF FOLLICLE-STIMULATING HORMONE AND, IN PRTICULAR, LETEINISING HORMONE IN THE ANTERIOR LOBE OF THE PITUITARY. THE SECRETION OF ENDOGENOUS GONADOTROPHIN-RELEASING HORMONE IS PULSATILE AND IS CONTROLLED BY SEVERAL FACTORS INCLUDING CIRCULATING SEX HORMONES.