CONVENTIONAL-DOSE REGIMENS :- 150 MCG/KG/BODY WT. DAILY IN DIVIDED DOSES FOR 4-7 DAYS OR MELPHALAN :- 250 MCG/KG DAILY FOR 4 DAYS OR 6 MG DAILY FOR 2-3 WEEKS. MAINTENANCE :- 1-3 MG OR UP TO 50 MCG/KG.
BY MOUTH, MULTIPLE MYELOMA, DOSE MAY VARY ACCORDING TO REGIMEN; TYPICAL DOSE 150 MICROGRAMS/KG DAILY FOR 4 DAYS, REPEATED EVERY 6 WEEKS
OVARIAN ADENOCARCINOMA, 200 MICROGRAMS/KG DAILY FOR 5 DAYS, REPEATED EVERY 4 - 8 WEEKS
ADVANCED BREAST CANCER, 150 MICROGRAMS/KG DAILY FOR 5 DAYS, REPEATED EVERY 6 WEEKS
POLYCYTHAEMIA VERA, INITIALLY, 6 - 10 MG DAILY REDUCED AFTER 5 - 7 DAYS TO 2 - 4 MG DAILY UNTIL SATISFACTORY RESPONSE THEN FURTHER REDUCE TO 2 - 6 MG PER WEEK
BY INTRAVENOUS INJECTION OR INFUSION AND REGIONAL ARTERIAL PERFUSION, CONSULT PRODUCT LITERATURE
DOSAGE REDUCTION OF UP TO 50% SHOULD BE CONSIDERED IN PATIENTS WITH RENAL INSUFFICIENCY (BUN ? 30 MG/DL)