TRICYCLIC ANTDEPRESSANTS :- POTENTIATES SEDATIVE EFFECTS OF ALCOHOL. ANTIPARKINSON AGENTS, ANTIPSYCHOTIC DRUGS, INCREASE RISK OF ANTICHOLINERGIC EFFECTS. REDUCE EFFECTS OF ANTIHYPERTENSIVES LIKE GUANETHIDINE BETHANIDINE ,BRETYLIUM, METHYLDOPA & CLONIDINE. MARKED HYPERPYREXIA CONVULSIONS AND COMA WITH MAOIS, HENCE SHOULD NOT BE USED WITHIN 2 WEEKS OF STOPPING MAOIS. HYPERPYREXIA HAS BEEN REPORTED WHEN TRYPTOMER IS ADMINISTERED WITH ANTICHOLINERGIC AGENTS OR WITH NEUROLEPTIC DRUGS. BARBITURATES & OTHER ENZYME INDUCER DRUGS LIKE RIFAMPICIN, PHENYTOIN,CARBAMAZEPINE CAN INCREASE ITS METABOLISM AND HENCE LOWERED PLASMA LEVELS & EFFICACY. CIMETIDINE, METHYLPHENIDATE, ANTIPSYCHOTICS, MAJOR TRANQUILIZERS,DEXTROPROPOXYPHENE,PROPAFENONE & CALCIUM CHANNEL BLOCKERS MAY REDUCE ITS METABOLISM LEADING TO INCREASED PLASMA CONC. & POSSIBILITY OF SIDE EFFECTS. CONCOMITANT ADMINISTRATION OF THYROID MEDICINE MAY LEAD TO ACCELERATED RESPONSE TO TRICYCLIC ANTIDEPRESSANTS & MAY PRECIPITATE CARDIAC ARRHYTHMIAS. POTENTIATES HYPERTENSIVE EFFECT OF SYMPATHOMIMETICS LIKE ADRENALINE, METHYLPENIDATE & NORADRENALINE.RISK OF ARRHYTHMIAS INCREASE WHEN ASTEMIZOLE, TERFENADINE, CISAPRIDE OR SOTALOL ARE GIVEN.ANTICOAGULANT ACTION OF COUMARINS IS POTENTIATED. ALPRAZOLAM & OTHER BENZODIAZEPINES POTENTIATE ITS ACTION.INCREASES THE EFFECT OF ORAL HYPOGLYCAEMICS AND INSULIN.CIGARETTE SMOKING ENHANCES THE METABOLISM. DIURETICS MAY LEAD TO HYPOTENSION.FLUCONAZOLE & TERBENAFINE INCREASE ITS PLASMA CONC.FURAZOLIDONE HAVING MONOAMINE OXIDASE INHIBITING ACTIVITY CAUSED TOXIC PSYCHOSIS.INCREASED RISK OF ARRHYTHMIAS WHEN GIVEN IN COMBINATION WITH DRUGS WHICH CAUSE PROLONGATION OF Q-T INTERVAL LIKE PIMOZIDE, THIORIDAZINE. RITONAVIR, ANTIVIRAL INCREASE THE PLASMA CONC OF TRICYCLIC ANTIDEPRESSANTS. MUSCLE RELAXANTS LIKE BACLOFEN EFFECT POTENTIATED WITH TRICYCLIC ANTIDEPRESSANTS. HIGH FIBRE DIET MAY REDUCE THE EFFECTS OF ANTIDEPRESSANTS. FENFLURAMINE INCREASES ITS CONC.COMCOMMITANT USE OF DISULFIRAM MAY CAUSE ACUTE ORGANIC BRAIN SYNDROME.