IT MAY PROLONG ELIMINATION OF DIAZEPAM, WARFARIN, PHENYTOIN, AMINOPHYLLINE, AND ANTITRYPSIN. CLARITHROMYCIN INCREASES ITS PLASMA CONCENTRATION BY 30% & MEAN HALF LIFE FROM 1.2 TO 1.6 HRS. IT REDUCES THE ABSORPTION OF KETOCONAZOLE, ITRACOCAZOLE.
OMEPRAZOLE BELONGS TO PROTON PUMP INHIBITORS AND HAS THE FOLLOWING INTERACTION INFORMATION:
ATAZANAVIR - OMEPRAZOLE SIGNIFICANTLY REDUCES PLASMA CONCENTRATION OF ATAZANAVIR -AVOID CONCOMITANT USE. CICLOSPORIN - OMEPRAZOLE POSSIBLY AFFECTS PLASMA CONCENTRATION OF CICLOSPORIN. CILOSTAZOL - OMEPRAZOLE INCREASES PLASMA CONCENTRATION OF CILOSTAZOL (RISK OF TOXICITY)-AVOID CONCOMITANT USE . CLARITHROMYCIN - PLASMA CONCENTRATION OF BOTH DRUGS INCREASED WHEN OMEPRAZOLE GIVEN WITH CLARITHROMYCIN CLOZAPINE - OMEPRAZOLE POSSIBLY REDUCES PLASMA CONCENTRATION OF CLOZAPINE AVOID CONCOMITANT USE OF CLOZAPINE WITH DRUGS THAT HAVE A SUBSTANTIAL POTENTIAL FOR CAUSING AGRANULOCYTOSIS. COUMARINS - OMEPRAZOLE POSSIBLY ENHANCES ANTICOAGULANT EFFECT OF COUMARINS CHANGE IN PATIENT'S CLINICAL CONDITION, PARTICULARLY ASSOCIATED WITH LIVER DISEASE, INTERCURRENT ILLNESS, OR DRUG ADMINISTRATION, NECESSITATES MORE FREQUENT TESTING. MAJOR CHANGES IN DIET (ESPECIALLY INVOLVING SALADS AND VEGETABLES) AND IN ALCOHOL CONSUMPTION MAY ALSO AFFECT ANTICOAGULANT CONTROL. DIAZEPAM - OMEPRAZOLE POSSIBLY INHIBITS METABOLISM OF DIAZEPAM (INCREASED PLASMA CONCENTRATION). ESCITALOPRAM - OMEPRAZOLE INCREASES PLASMA CONCENTRATION OF ESCITALOPRAM . METHOTREXATE - OMEPRAZOLE POSSIBLY REDUCES EXCRETION OF METHOTREXATE (INCREASED RISK OF TOXICITY). PHENYTOIN - OMEPRAZOLE POSSIBLY ENHANCES EFFECTS OF PHENYTOIN. SAQUINAVIR - OMEPRAZOLE POSSIBLY INCREASES PLASMA CONCENTRATION OF SAQUINAVIR. TACROLIMUS - OMEPRAZOLE POSSIBLY INCREASES PLASMA CONCENTRATION OF TACROLIMUS INTERACTIONS DO NOT GENERALLY APPLY TO TACROLIMUS USED TOPICALLY; RISK OF FACIAL FLUSHING AND SKIN IRRITATION WITH ALCOHOL CONSUMPTION DOES NOT APPLY TO TACROLIMUS TAKEN SYSTEMICALLY. VORICONAZOLE - PLASMA CONCENTRATION OF OMEPRAZOLE INCREASED BY VORICONAZOLE (REDUCE DOSE OF OMEPRAZOLE)