IT IS ADMINISTERED BY DEEP I.M. INJECTION.
FOR EARLY SYPHILIS :- 1.8 GM BY DEEP I.M. INJ. USUALLY AS 2 INJECTIONS AT SEPARATE SITES. IN LATE SYPHILIS :- 1.8 GM AT WEEKLY INTERVALS FOR 3 CONSECUTIVE WEEKS. CHILDREN OVER 2 YEARS OF AGE :- 37.5 MG/KG/BODY WT.
FOR THE TREATMENT OF OTHER TREPONEMAL INFECTIONS SUCH AS YAWS, PINTA, AND ENDEMIC SYPHILIS, STREPTOCOCCAL PHARYNGITIS AND THE PRIMARY PREVENTION OF RHEUMATIC FEVER, AND ACUTE RHEUMATIC FEVER :- 900 MG FOR ADULTS AND 450 MG FOR CHILDREN.
OR
SEVERE INFECTIONS DUE TO SUSCEPTIBLE STRAINS OF STREPTOCOCCI, PNEUMOCOCCI, AND STAPHYLOCOCCI-BACTEREMIA, PNEUMONIA, ENDOCARDITIS, PERICARDITIS, EMPYEMA, MENINGITIS, AND OTHER SEVERE INFECTIONS-A MINIMUM OF 5 MILLION UNITS DAILY.
SYPHILIS - AQUEOUS PENICILLIN G MAY BE USED IN THE TREATMENT OF ACQUIRED AND CONGENITAL SYPHILIS, BUT BECAUSE OF THE NECESSITY OF FREQUENT DOSAGE, HOSPITALIZATION IS RECOMMENDED. DOSAGE AND DURATION OF THERAPY WILL BE DETERMINED BY AGE OF PATIENT AND STAGE OF THE DISEASE.
GONORRHEAL ENDOCARDITIS - A MINIMUM OF 5 MILLION UNITS DAILY.
MENINGOCOCCIC MENINGITIS - 1-2 MILLION UNITS INTRAMUSCULARLY EVERY 2 HOURS, OR CONTINUOUS IV DRIP OF 20-30 MILLION UNITS/DAY.
ACTINOMYCOSIS - 1-6 MILLION UNITS/DAY FOR CERVICOFACIAL CASES; 10-20 MILLION UNITS/DAY FOR THORACIC AND ABDOMINAL DISEASE.
CLOSTRIDIAL INFECTIONS - 20 MILLION UNITS/DAY; PENICILLIN IS ADJUNCTIVE THERAPY TO ANTITOXIN.
FUSOSPIROCHETAL INFECTIONS - SEVERE INFECTIONS OF OROPHARYNX, LOWER RESPIRATORY TRACT, AND GENITAL AREA-5-10 MILLION UNITS/DAY.
RAT-BITE FEVER (SPIRILLUM MINUS OR STREPTOBACILLUS MONILIFORMIS) - 12-15 MILLION UNITS/DAY FOR 3-4 WEEKS.
LISTERIA INFECTIONS (LISTERIA MONOCYTOGENES)
NEONATES - 500,000 TO 1 MILLION UNITS/DAY
ADULTS WITH MENINGITIS - 15-20 MILLION UNITS/DAY FOR 2 WEEKS.
ADULTS WITH ENDOCARDITIS - 15-20 MILLION UNITS/DAY FOR 4 WEEKS.
PASTEURELLA INFECTIONS (PASTEURELLA MULTOCIDA)
BACTEREMIA AND MENINGITIS - 4-6 MILLION UNITS/DAY FOR 2 WEEKS.
ERYSIPELOID (ERYSIPELOTHRIX INSIDIOSA)
ENDOCARDITIS - 2-20 MILLION UNITS/DAY FOR 4-6 WEEKS.
GRAM-NEGATIVE BACILLARY INFECTIONS (E. COLI, ENTEROBACTER AEROGENES, A. FAECALIS, SALMONELLA, SHIGELLA AND PROTEUS MIRABILIS)
BACTEREMIA - 20-80 MILLION UNITS/DAY.
DIPHTHERIA (CARRIER STATE) - 300,000-400,000 UNITS OF PENICILLIN/DAY IN DIVIDED DOSES FOR 10-12 DAYS.
ANTHRAX - A MINIMUM OF 5 MILLION UNITS OF PENICILLIN/DAY IN DIVIDED DOSES UNTIL CURE IS EFFECTED.
FOR PROPHYLAXIS AGAINST BACTERIAL ENDOCARDITIS IN PATIENTS WITH CONGENITAL HEART DISEASE OR RHEUMATIC OR OTHER ACQUIRED VALVULAR HEART DISEASE, WHEN UNDERGOING DENTAL PROCEDURES OR SURGICAL PROCEDURES OF THE UPPER RESPIRATORY TRACT, USE A COMBINED PARENTERAL-ORAL REGIMEN. ONE MILLION UNITS OF AQUEOUS CRYSTALLINE PENICILLIN G (30,000 UNITS/KG IN CHILDREN) INTRAMUSCULARLY, MIXED WITH 600,000 UNITS PROCAINE PENICILLIN G (600,000 UNITS FOR CHILDREN) SHOULD BE GIVEN ONE-HALF TO ONE HOUR BEFORE THE PROCEDURE. ORAL PENICILLIN V (PHENOXYMETHYL PENICILLIN), 500 MG FOR ADULTS OR 250 MG FOR CHILDREN LESS THAN 60 LB, SHOULD BE GIVEN EVERY 6 HOURS FOR 8 DOSES. DOSES FOR CHILDREN SHOULD NOT EXCEED RECOMMENDATIONS FOR ADULTS FOR A SINGLE DOSE OR FOR A 24 HOUR PERIOD.