PLASMINOGEN ACTIVATORS ARE SUBSTANCES THAT CONVERT FIBRIN BOUND PLASMINOGEN TO ACTIVE FORM PLASMIN, RESULTING IN FIBRINOLYSIS AND DISSOLUTION OF CLOT. THESE CAN BE PRODUCED BY RECOMBINANT DNA TECHNOLOGY OR CAN BE EXTRACTED FROM CULTURED HUMAN MELANOMA CELLS. IT SELECTIVELY ACTIVATES GEL PHASE PLASMINOGEN THAT IS BOUND TO FIBRIN.ITS USE CAN AVOID BLEEDING WHICH OCCURS WITH STREPTOKINASE AND UROKINASE DUE TO SIMULTANEOUS ACTIVATION OF SOLUBLE PLASMINOGEN.