IN MANY OF THE COMBINATION REGIMENS IT HAS BEEN GIVEN BY MOUTH TO ADULTS AND CHILDREN IN DOSES OF THE EQUIVALENT OF PROCARBAZINE 100 MG/M2 ON DAYS 1 TO 14 OF EACH 4- OR 6-WEEK CYCLE.
IF USED AS A SINGLE AGENT IN ADULTS A DOSE EQUIVALENT TO 50 MG OF PROCARBAZINE DAILY, INCREASED BY 50 MG DAILY TO 250 TO 300 MG DAILY IN DIVIDED DOSES HAS BEEN SUGGESTED IN THE UK, WHILE IN THE USA THE RECOMMENDED REGIMEN IS 2 TO 4 MG/KG DAILY FOR THE FIRST WEEK, SUBSEQUENTLY INCREASED TO 4 TO 6 MG/KG DAILY, DOSES BEING GIVEN TO THE NEAREST 50 MG. THESE DOSES ARE CONTINUED UNTIL MAXIMUM RESPONSE IS ACHIEVED OR LEUCOPENIA, THROMBOCYTOPENIA, OR OTHER SIGNS OF TOXICITY ENSUE.
MAINTENANCE DOSES ARE USUALLY 50 TO 150 MG DAILY, OR 1 TO 2 MG/KG, DAILY, UNTIL A CUMULATIVE DOSE OF AT LEAST 6 G HAS BEEN GIVEN. IN CHILDREN, INITIAL DAILY DOSES OF THE EQUIVALENT OF 50 MG/M2 HAVE BEEN SUGGESTED IN THE USA (UK PRODUCT INFORMATION SIMPLY SUGGESTS A DOSE OF 50 MG), INCREASED TO 100 MG/M2 AND THEN ADJUSTED ACCORDING TO RESPONSE.