BY MOUTH, NAUSEA AND VOMITING, ACUTE ATTACK, 20 MG INITIALLY THEN 10 MG AFTER 2 HOURS; PREVENTION 5 - 10 MG 2 - 3 TIMES DAILY; CHILD (OVER 10 KG ONLY) 250 MICROGRAMS/KG 2 - 3 TIMES DAILY
LABYRINTHINE DISORDERS, 5 MG 3 TIMES DAILY, GRADUALLY INCREASED IF NECESSARY TO 30 MG DAILY IN DIVIDED DOSES, THEN REDUCED AFTER SEVERAL WEEKS TO 5 - 10 MG DAILY; CHILD NOT RECOMMENDED
BY DEEP INTRAMUSCULAR INJECTION, NAUSEA AND VOMITING, 12.5 MG WHEN REQUIRED FOLLOWED IF NECESSARY AFTER 6 HOURS BY AN ORAL DOSE, AS ABOVE.
PSYCHOSES:
IN UK, PROCHLORPERAZINE BY MOUTH IN A DOSE OF 12.5 MG TWICE DAILY FOR 7 DAYS ADJUSTED GRADUALLY TO 75 TO 100 MG DAILY ACCORDING TO RESPONSE; SOME PATIENTS MAY BE MAINTAINED ON DOSES OF 25 TO 50 MG DAILY. THE EQUIVALENT OF PROCHLORPERAZINE MALEATE 25 MG TWO OR THREE TIMES DAILY MAY BE GIVEN BY THE RECTAL ROUTE OR 12.5 TO 25 MG OF THE MESILATE TWO OR THREE TIMES DAILY BY DEEP INTRAMUSCULAR INJECTION
CHILDREN'S DOSES : OWING TO THE RISK OF SEVERE EXTRAPYRAMIDAL REACTIONS, PROCHLORPERAZINE SHOULD BE USED WITH EXTREME CAUTION IN CHILDREN; NOT RECOMMENDED FOR VERY YOUNG CHILDREN OR THOSE WEIGHING LESS THAN 10 KG. WHERE USE IN CHILDREN IS UNAVOIDABLE, 250 MICROGRAMS/KG OF THE MALEATE OR MESILATE MAY BE GIVEN 2 OR 3 TIMES DAILY BY MOUTH TO CHILDREN AGED 1 YEAR AND OVER FOR THE PREVENTION AND TREATMENT OF NAUSEA AND VOMITING; THE INTRAMUSCULAR AND RECTAL ROUTES ARE CONSIDERED UNSUITABLE. ALTERNATIVELY, THE BNFC SUGGESTS GIVING ORAL DOSES, REPEATED UP TO 3 TIMES DAILY IF NECESSARY, ACCORDING TO AGE AS FOLLOWS: 1 TO 5 YEARS, 1.25 TO 2.5 MG; 5 TO 12 YEARS, 2.5 TO 5 MG. ALTHOUGH NOT LICENSED, IT HAS ALSO SUGGESTED THAT SIMILAR DOSES MAY BE GIVEN BY INTRAMUSCULAR INJECTION TO CHILDREN AGED 2 YEARS AND OVER, OR RECTALLY AS SUPPOSITORIES TO THOSE AGED 1 YEAR AND OVER.
IN USA, PROCHLORPERAZINE IS GIVEN INITIAL DOSES EQUIVALENT TO 5 OR 10 MG OF THE BASE 3 OR 4 TIMES DAILY BY MOUTH ADJUSTED ACCORDING TO RESPONSE UP TO A MAXIMUM OF 150 MG OF BASE DAILY. IN ACUTE CASES BY IM INJ EQUIVALENT TO 10 TO 20 MG OF THE BASE AND REPEATED EVERY 2 TO 6 HOURS IF NECESSARY.