OPIOIDS, MUSCLE RELAXANTS, NEUROMUSCULAR BLOCKERS INCREASE ANAESTHESIA, RESPIRATORY DEPRESSION (OPIOIDS) AND DECREASE THE HEART RATE (SUXA-METHONIUM). MAY CAUSE HEART BLOCK / ASYSTOLE. MIDAZOLAM, THIOPENTOL, FENTANYL, ALTENTANYL INCREASES HYPNOSIS. DOSE OF PROPOFOL SHOULD BE REDUCED IF GIVEN WITH N2O & HALOGENATED ANAESTHETICS. INCREASED HYPOTENSIVE EFFECT SEEN WITH ACE INHIBITORS, TRICYCLIC & MAO ANTIDEPRESSANTS, ANTIPSYCHOTIC AND BETA BLOCKERS.