IT IS THE PYRAZINE ANALOG OF NOCOTINAMIDE. WHEN THIS DRUG IS USED ALONE THE DISEASE IS INITIALLY CONTROLLED BUT SOON REPLASES BECAUSE MICROORGANISMS RAPIDLY BECOME RESISTANT. WHEN IT IS ADMINISTERED SIMULTANEOUSLY WITH ISONLAZID, THE BECTERIA REMAIN SENSITIVE TO PYRAZINAMIDE. IT IS WELL ABSORBED FROM THE GASTROINTESTINAL TRACT AND DISTRIBUTED THROUGHOUT THE BODY. PYRAZINAMIDE HAS BEEN STRONGLY RECOMMENDED FOR USE IN INDIVIDUALS WHO ARE TO BE SUBJECTED TO PULMONARY SURGERY.