TORSADE DE POINTES HAS BEEN REPORTED IN PATIENTS RECEIVING SPARFLOXACIN CONCOMITANTLY WITH DISOPYRAMIDE AND AMIODARONE. CONSEQUENTLY, SPARFLOXACIN IS CONTRAINDICATED FOR INDIVIDUALS RECEIVING THESE DRUGS AS WELL AS OTHER QT C -PROLONGING ANTIARRHYTHMIC DRUGS REPORTED TO CAUSE TORSADE DE POINTES SUCH AS CLASS IA ANTIARRHYTHMIC AGENTS (E.G., QUINIDINE, PROCAINAMIDE), CLASS III ANTIARRHYTHMIC AGENTS (E.G., SOTALOL), AND BEPRIDIL. AVOID THE CONCOMITANT PRESCRIPTION OF MEDICATIONS KNOWN TO PROLONG THE QT C INTERVAL, E.G., ERYTHROMYCIN, TERFENADINE, ASTEMIZOLE, CISAPRIDE, PENTAMIDINE, TRICYCLIC ANTIDEPRESSANTS, SOME ANTIPSYCHOTICS INCLUDING PHENOTHIAZINES.
CONCURRENT ADMINISTRATION OF CHLOROQUINE WITH QUINOLONES SHOULD BE UNDERTAKEN WITH CARE AS BOTH DRUGS ARE NEUROTOXIC. MAGNESIUM, ALUMINIUM, CALCIUM, IRON AND ZINC ANTACIDS DECREASE ABSORPTION. RIFAMCIN REDUCE SERUM CONCENTRATION. CNS EXCITATION OCCUR WITH CONCURRENT ADMINISTRATION OF QUINOLONES AND NSAIDS. OPIOID ANALGESICS (PAPAVERETUM) ALSO INTERACT. NO CLINICALLY SIGNIFICANT INTERACTION WHEN USED WITH CYCLOSPORIN, WARFARIN, THEOPHYLLINE, DIGOXIN, CIMETIDINE, GLIBENCLAMIDE, PROBENECID. CALCIUM CHANNEL BLOCKERS AND DIGOXIN MAY CAUSE HIGHER BLOCKS WITH CONCOMMITANT USE OF OTHER QUINOLONE LIKE GATIFLOXACIN.ORAL HYPOGLYCAEMIC IN ASSOCIATION WITH GATIFLOXACIN MAY CAUSE PROLONGED HYPOGLYCAEMIA. SO CAUTION SHOULD BE TAKEN WITH SPARFLOXACIN OR OTHER QUINOLONES USE.