MONOSULFIRAM INHIBITS HEPATIC ENZYMES AND MAY INTERFERE WITH THE METABOLISM OF OTHER DRUGS TAKEN AT THE SAME TIME. IT ENHANCES THE EFFECTS OF PHENYTOIN AND COUMARIN ANTICOAGULANTS. IT INHIBITS THE METABOLISM AND EXCRETION OF RIFAMPICIN, PETHIDINE, MORPHINE, AND AMPHETAMINES. CONCURRENT USED WITH ISONIAZID OR METRONIDAZOLE THE TOXIC REACTIONS HAVE BEEN OCCUR.