IN HYPERTENSION TIMOLOL MALEATE IS USUALLY GIVEN IN INITIAL DOSES OF 10 MG DAILY BY MOUTH, INCREASED ACCORDING TO RESPONSE AT INTERVALS OF 7 OR MORE DAYS. USUAL MAINTENANCE DOSES ARE 10 TO 40 MG DAILY, BUT DOSES UP TO 60 MG DAILY MAY BE REQUIRED IN SOME PATIENTS; DOSES ABOVE 30 MG DAILY SHOULD BE GIVEN IN 2 EQUALLY DIVIDED DOSES.
IN ANGINA PECTORIS THE INITIAL DOSE IS 5 MG TWICE DAILY, INCREASED AT INTERVALS OF 3 OR MORE DAYS BY 10 MG DAILY. MOST PATIENTS RESPOND TO 35 TO 45 MG DAILY IN DIVIDED DOSES, BUT SOME PATIENTS MAY REQUIRE UP TO 60 MG DAILY.
IN PATIENTS WHO HAVE HAD A MYOCARDIAL INFARCTION TIMOLOL MALEATE IS GIVEN IN INITIAL DOSES OF 5 MG TWICE DAILY FOR 2 DAYS, STARTING 7 TO 28 DAYS AFTER INFARCTION, AND INCREASED SUBSEQUENTLY IN THE ABSENCE OF ANY CONTRA-INDICATING ADVERSE EFFECTS, TO 10 MG TWICE DAILY.
DOSES OF 10 TO 20 MG DAILY OF TIMOLOL MALEATE ARE USED IN THE PROPHYLAXIS OF MIGRAINE.
EYE DROPS CONTAINING TIMOLOL MALEATE OR HEMIHYDRATE EQUIVALENT TO 0.25 AND 0.5% OF TIMOLOL ARE INSTILLED TWICE DAILY TO REDUCE RAISED INTRA-OCULAR PRESSURE IN OPEN-ANGLE GLAUCOMA AND OCULAR HYPERTENSION. ONCE-DAILY INSTILLATION MAY SUFFICE WHEN THE INTRA-OCULAR PRESSURE HAS BEEN CONTROLLED. GEL-FORMING EYE DROPS ARE ALSO AVAILABLE THAT ARE INSTILLED ONCE DAILY.DOSES OF 10 TO 20 MG DAILY OF TIMOLOL MALEATE ARE USED IN THE PROPHYLAXIS OF MIGRAINE.