THE USUAL INITIAL DAILY DOSE IN THE UK IN THE MANAGEMENT OF SPASTICITY IS THE EQUIVALENT OF 2 MG OF THE BASE GIVEN AS A SINGLE DOSE. THE DOSE MAY BE INCREASED THEREAFTER ACCORDING TO RESPONSE IN STEPS OF 2 MG AT INTERVALS OF AT LEAST 3 TO 4 DAYS, USUALLY UP TO 24 MG DAILY GIVEN IN 3 OR 4 DIVIDED DOSES. A SIMILAR SCHEDULE, WITH AN INITIAL DAILY DOSE OF 4 MG, INCREASED AS REQUIRED IN STEPS OF 2 TO 4 MG, IS USED IN THE USA. THE MAXIMUM RECOMMENDED DOSE IS 36 MG DAILY. MAINTENANCE DOSES HAVE BEEN GIVEN IN SOME COUNTRIES IN THE FORM OF MODIFIED-RELEASE PREPARATIONS. FOR DOSAGE IN RENAL IMPAIRMENT.
IN THE TREATMENT OF PAINFUL MUSCLE SPASM TIZANIDINE HYDROCHLORIDE IS GIVEN IN DOSES EQUIVALENT TO 2 TO 4 MG OF THE BASE THREE TIMES DAILY.