BY MOUTH, INITIALLY 600 MG DAILY IN 2 DIVIDED DOSES, PREFERABLY AFTER FOOD, INCREASED BY 200 MG DAILY EVERY 3 DAYS TO MAX. 2.5 G DAILY, USUAL MAINTENANCE DOSE 1 - 2 G DAILY (20 - 30 MG/KG DAILY); CHILD BODY-WEIGHT UP TO 20 KG, INITIALLY 20 MG/KG DAILY IN DIVIDED DOSES, MAY BE INCREASED PROVIDED PLASMA CONCENTRATION MONITORED (DOSE ABOVE 40 MG/KG DAILY ALSO MONITOR CLINICAL CHEMISTRY AND HAEMATOLOGICAL PARAMETERS); CHILD UNDER 12 YEARS BODY-WEIGHT OVER 20 KG, INITIALLY 400 MG DAILY IN DIVIDED DOSES INCREASED ACCORDING TO RESPONSE (USUAL RANGE 20 - 30 MG/KG DAILY); MAX. 35 MG/KG DAILY
BY INTRAVENOUS INJECTION (OVER 3 - 5 MINUTES) OR BY INTRAVENOUS INFUSION, CONTINUATION OF VALPROATE TREATMENT, SAME AS CURRENT DOSE BY ORAL ROUTE
INITIATION OF VALPROATE THERAPY, BY INTRAVENOUS INJECTION (OVER 3 - 5 MINUTES), 400 - 800 MG (UP TO 10 MG/KG) FOLLOWED BY INTRAVENOUS INFUSION UP TO MAX. 2.5 G DAILY; CHILD UNDER 12 YEARS, USUALLY 20 - 30 MG/KG DAILY, MAY BE INCREASED PROVIDED PLASMA CONCENTRATION MONITORED (DOSE ABOVE 40 MG/KG DAILY ALSO MONITOR CLINICAL CHEMISTRY AND HAEMATOLOGICAL PARAMETERS)