ADULTS : SLOW I.V.INJECTION (1MG/ML OF NACL) 100 MG/KG/WEEK, INCREASED BY 50 MCG/KG UPTO MAX 500 MCG/KG OR UNTIL THE WBC COUNT HAS FALLEN TO 3,000 /C.M.-2 MAINT : GIVEN EVERY 7-14 DASY (1 INCREMENT SMALLER THAN THE MAX. DOSE.
OR
THE USUAL DOSE IS ABOUT 6 MG/M2, NOT MORE OFTEN THAN EVERY 7 DAYS, ALTHOUGH DOSES STARTING AT 3.7 MG/M2 AND INCREASING TO 18.5 MG/M2 HAVE BEEN GIVEN AS A SINGLE AGENT. IF A MAINTENANCE DOSE IS REQUIRED, IT MAY BE GIVEN EVERY 7 DAYS PROVIDED WHITE CELL COUNTS PERMIT, AND SHOULD BE ONE DECREMENT SMALLER THAN THE MAXIMUM DOSE THAT THE PATIENT IS ABLE TO TOLERATE WITHOUT SERIOUS LEUCOPENIA OCCURRING.
CHILDREN : INCREASED BY 1.25 MG/SQM. WEEKLY TO A MAX OF 7.5MG SQM. SEE LIT FOR DETAILS.