RIBOFLAVIN IS USED IN THE TREATMENT AND PREVENTION OF RIBOFLAVIN DEFICIENCY. IT IS USUALLY GIVEN IN DOSES OF 1 OR 2 MG BY MOUTH FOR PROPHYLAXIS, AND DOSES OF UP TO 30 MG DAILY IN DIVIDED DOSES ARE USED FOR TREATMENT. RIBOFLAVIN, AS THE SODIUM PHOSPHATE, IS ALSO A COMPONENT OF INTRAMUSCULAR OR INTRAVENOUS VITAMINS B AND C INJECTIONS; RIBOFLAVIN SODIUM PHOSPHATE 1.27 G IS EQUIVALENT TO ABOUT 1 G OF RIBOFLAVIN.
GLUTARIC ACIDURIA.
MILDER FORMS OF GLUTARIC ACIDURIA TYPE II MAY RESPOND TO RIBOFLAVIN. TREATMENT WITH RIBOFLAVIN 50 MG DAILY RESULTED IN PROGRESSIVE IMPROVEMENT IN A 4-YEAR-OLD BOY, WITH FULL RECOVERY AFTER 1 YEAR. HIS BROTHER, WHO HAD SUSTAINED PERMANENT BRAIN DAMAGE AFTER EPILEPTIC SEIZURES, SHOWED MODERATE CLINICAL IMPROVEMENT WITH RIBOFLAVIN THERAPY. IN AN ADULT PATIENT WITH A HISTORY OF RECURRENT PANCREATITIS AND EXERCISE INTOLERANCE, TREATMENT WITH RIBOFLAVIN 120 MG DAILY AND LEVOCARNITINE RESULTED IN NO FURTHER EPISODES, ALTHOUGH ABNORMAL CONCENTRATIONS OF AMINO ACIDS WERE STILL APPARENT IN HER URINE.
MIGRAINE.
RESULTS FROM OPEN STUDIES AND A PLACEBO-CONTROLLED TRIAL HAVE SUGGESTED THAT RIBOFLAVIN IN HIGH DOSES (400 MG DAILY) MIGHT BE OF SOME BENEFIT IN THE PROPHYLAXIS OF MIGRAINE ATTACKS .