ETHACRYNIC ACID, DISPLACE WARFARIN FROM PLASMA PROTEIN; SO A REDUCTION IN THE USUAL ANTICOAGULANT DOSAGE MAY BE REQUIRED.
ETHACRINIC ACID MAY INCREASE THE RISK OF GASTRIC HEMORRHAGE ASSOCIATED WITH CORTICOSTEROID TREATMENT. AMINOGLYCOSIDE ANTIBIOTICS MAY ENHANCE THE RISK OF DEAFNESS, POTENTIATES ANTI-HYPERTENSIVES. CAUSES LITIHUM TOXICITY IN THOSE RECEIVING BOTH DRUGS. WITH CO-TRIMOXAZOLE PRODUCES THROMBOCYTOPENIA. NSAIDS DIMINISH THE DIURETIC EFFECTS.
ANTIHYPERTENSIVE EFFECTS OF IT MAY BE ANTAGONISED BY DRUGS THAT CAUSE FLUID RETENTION, SUCH AS CORTICOSTEROIDS, NSAIDS, OR CARBENOXOLONE. POSTURAL HYPOTENSION ASSOCIATED WITH DIURETIC THERAPY MAY BE ENHANCED BY CONCOMITANT INGESTION OF ALCOHOL, BARBITURATES, OR OPIOID ANALGESIC