A DIMINISHED HYPOGLYCAEMIC EFFECT, POSSIBLY REQUIRRING AN INCREASED DOSE OF ACETAHEXAMIDE, HAS BEEN SEEN OR MIGHT BE EXPECTED ON THEORETICAL GROUNDS WITH ADRENALINE, AMINOGLUTETHIMIDE, CHLORPROMAZINE, CORTICOSTEROIDS, DIAZOXIDE, ORAL CONTRACEPTIVES, RIFAMPICIN, AND THIAZIDE DIURETICS. AN INCREASED HYPOGLYCAEMIC EFFECT HAS OCCURRED OR MIGHT BE EXPECTED WITH ACE INHIBITORS, ALCOHOL, ALLOPURINOL, SOME ANALGESCS, AZOLE ANTIFUNGALS, CHLORAMPHENICOL, CIMETIDINE, CLOFIBRATE AND COUMARIN ANTICOAGULANTS, HALOFENATE, HEPARIN, MAOIS, OCTREOTIDE, RANITIDINE SULPHINPYRAZONE, SULPHONAMIDES, TETRACYCLINES, TRICYCLIC ANTIDEPRESSANTS , AND THYROID HORMONES. BETA BLOCKERS HAVE BEEN REPORTED BOTH TO INCREASE HYPOGLYCAEMIA AND TO MASK THE TYPICAL SYMPATHETIC WARNING SIGNS. THERE ARE SPORADIC REPORTS OF MARKED HYPOGLYCAEMIA DEVELOPING IN PATIENTS TAKING A ACETAHEXAMIDE WHO ARE GIVEN AN ACE INHIBITORS.