THE INITIAL DOSE OF SULFINPYRAZONE IN THE UK IS 100 TO 200 MG DAILY (THE USA ALLOWS UP TO 200 MG TWICE DAILY), TAKEN WITH MEALS OR MILK. THIS MAY BE GRADUALLY INCREASED OVER 1 TO 3 WEEKS UNTIL A DAILY DOSAGE OF 600 MG IS REACHED; UP TO 800 MG DAILY MAY BE GIVEN IF NECESSARY. AFTER THE PLASMA-URATE CONCENTRATION HAS BEEN CONTROLLED, THE DAILY MAINTENANCE DOSE MAY BE REDUCED TO AS LOW AS 200 MG. AN ADEQUATE FLUID INTAKE IS REQUIRED TO PREVENT FORMATION OF URIC ACID RENAL CALCULI.