CONCURRENTLY ADMINISTERED WITH ADRENALINE OR OTHER SYMPATHOMIMETICS, THE VENTRICULAR FIBRILLATION MAY OCCUR. CONCURRENT USE WITH CNS DEPRESSANT LIKE OPIOIDS, BENZODIAZEPINES & SEDATIVES MAY REQUIRE LOWER DOSES OF ENFLURANE FOR ANAESTHESIA THE EFFECT OF COMPETITIVE NEUROMUSCULAR BLOCKERS SUCH AS ATRACURIUM ARE ENHANCED BY ENFLURANE. THE METABOLISM & HENCE TOXICITY OF SEVOFLURANE MAY BE INCREASED BY DRUGS OR COMPOUNDS THAT INDUCE CYTOCHROME P450 ISOENZYME CYP2E1 INCLUDING ISONIAZID & ALCOHOL