DEPRESSION :- 100 MG TWICE DAILY, INCREASED AFTER AT LEAST 3 DAYS TO 100 MG THREE TIMES DAILY. SEVERE CASES :- 150 MG THREE TIMES DAILY.
SMOKING CESSATION :- ADULT OVER 18 YEARS, START 1 - 2 WEEKS BEFORE TARGET STOP DATE, INITIALLY 150 MG DAILY FOR 6 DAYS THEN 150 MG TWICE DAILY (MAX. SINGLE DOSE 150 MG, MAX. DAILY DOSE 300 MG; MINIMUM 8 HOURS BETWEEN DOSES); PERIOD OF TREATMENT 7 - 9 WEEKS; DISCONTINUE IF ABSTINENCE NOT ACHIEVED AT 7 WEEKS; CONSIDER MAX. 150 MG DAILY IN PATIENTS WITH RISK FACTORS FOR SEIZURES (SEE CSM ADVICE ABOVE); ELDERLY MAX. 150 MG DAILY