ROFECOXIB IS A NONSTEROIDAL ANTI-INFLAMMATORY DRUG THAT EXHIBITS ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITIES IN ANIMAL MODELS. THE MECHANISM OF ACTION OF ROFECOXIB IS BELIEVED TO BE DUE TO INHIBITION OF PROSTAGLANDIN SYNTHESIS, VIA INHIBITION OF CYCLOOXYGENASE-2 (COX-2). AT THERAPEUTIC CONCENTRATIONS IN HUMANS, ROFECOXIB DOES NOT INHIBIT THE CYCLOOXYGENASE-1 (COX-1) ISOENZYME.