REDUCED EFFICACY WITH CONCURRENT USE OF CARBAMAZEPINE, PHENYTOIN, PRIMIDONE AND BARBITURATES, RIFAMPICIN, EPHEDRINE, GRISEOVIN SINCE THESE INCREASE ITS METABOLISM.. PEPTIC ULCER, AND G.I. BLEEDING WITH CONCURRENT NSAIDS ADMINISTRATION. DECREASES SERUM CONCENTRATION OF SALICYLATES AND ANTIMUSCARINIC AGENTS. CONCURRENT ADMINISTRATION OF CORTICOSTEROIDS WITH PATASSIUM-DEPLETING DIURETICS, SUCH AS THIAZIDES OR FRUSEMIDE, MAY CAUSE EXCESSIVE POTASSIUM LOSS.
REDUSES EFFECT BUT ENHANCES TOXIC EFFECTS OF IMIPRAMINE. REDUCES EFFECT OF ANTICOAGULANTS,HYPOGLYCAEMIC, ANTIHYPERTENSIVE AGENTS. DICUMAROL EFFECT IS DIMINISHED BUT WARFARIN, NICOUMALONE EFFECT IS POTENTIATED. . INCREASES TOXICITY OF CYCLOSPORIN.DECREASED CLEARANCE OF XANTHINES. INCREASED CLEARANCE OF PARACETAMOL, MORPHINE, CLOFIBRATE. NITRAZEPAM AND OTHER BENZODIAZEPAMS EFFECT MAY BE ENHANCED