FOR INDUCTION THERAPY IN ADULT PATIENTS WITH AML THE FOLLOWING DOSE SCHEDULE IS RECOMMENDED:
IDAMYCIN PFS INJECTION 12 MG/M 2 DAILY FOR 3 DAYS BY SLOW INTRAVENOUS INJECTION INTO A FAST-RUNNING INFUSION OF SODIUM CHLORIDE 0.9% OR GLUCOSE 5% OVER 5 TO 15 MINUTES IN COMBINATION WITH CYTARABINE. IN PATIENTS WITH UNEQUIVOCAL EVIDENCE OF LEUKEMIA AFTER THE FIRST INDUCTION COURSE, A SECOND COURSE MAY BE ADMINISTERED. ADMINISTRATION OF THE SECOND COURSE SHOULD BE DELAYED IN PATIENTS WHO EXPERIENCE SEVERE MUCOSITIS, UNTIL RECOVERY FROM THIS TOXICITY HAS OCCURRED, AND A DOSE REDUCTION OF 25% IS RECOMMENDED.
A SIMILAR DOSE, AS A SINGLE AGENT, HAS BEEN GIVEN IN ACUTE LYMPHOBLASTIC LEUKAEMIA. AN ALTERNATIVE DOSAGE SCHEDULE IN ACUTE MYELOID LEUKAEMIA IS 8 MG/M2 GIVEN DAILY FOR 5 DAYS, EITHER ALONE OR IN COMBINATION THERAPY. IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA A DOSE OF 10 MG/M2 DAILY FOR 3 DAYS AS A SINGLE AGENT HAS BEEN SUGGESTED. WHEN THE IV ROUTE CANNOT BE USED, IDARUBICIN HYDROCHLORIDE MAY BE GIVEN BY MOUTH.
BY MOUTH:
IN PATIENTS WITH REFRACTORY BREAST CANCER, ADVANCED BREAST CANCER, MONOTHERAPY : IDARUBICIN HAS BEEN GIVEN IN DOSES OF 45 MG/M2 AS A SINGLE DOSE OR 15 MG/M2 DAILY FOR 3 CONSECUTIVE DAYS; REPEAT EVERY 3 - 4 WEEKS
ACUTE NON-LYMPHOCYTIC LEUKAEMIA, MONOTHERAPY, 30 MG/M2 DAILY FOR 3 DAYS OR IN COMBINATION THERAPY, 15 - 30 MG/M2 DAILY FOR 3 DAYS
ADULT ACUTE MYELOID LEUKAEMIA : AS A SINGLE AGENT IS 30 MG/M2 DAILY FOR 3 DAYS; 15 TO 30 MG/M2 MAY BE GIVEN DAILY FOR 3 DAYS WHEN USED WITH OTHER DRUGS.
NOTE MAX. CUMULATIVE DOSE BY MOUTH (FOR ALL INDICATIONS) 400 MG/M2