COADMINISTRATION DECREASED THE C MAX AND AUC OF KETOCONAZOLE BY 21% AND 10%, RESPECTIVELY, AND DID NOT SIGNIFICANTLY AFFECT THE PHARMACOKINETICS OF CITALOPRAM. BECAUSE LITHIUM MAY ENHANCE THE SEROTONERGIC EFFECTS OF ESCITALOPRAM, CAUTION SHOULD BE EXERCISED WHEN ESCITALOPRAM AND LITHIUM ARE COADMINISTERED. MARKED HYPERPYREXIA CONVULSIONS AND COMA WITH MAOIS, HENCE SHOULD NOT BE USED WITHIN 2 WEEKS OF STOPPING MAOIS. SEROTONIN RELEASE BY PLATELETS PLAYS AN IMPORTANT ROLE IN HEMOSTASIS. STUDIES HAVE DEMONSTRATED AN ASSOCIATION BETWEEN USE OF PSYCHOTROPIC DRUGS THAT INTERFERE WITH SEROTONIN REUPTAKE AND THE OCCURRENCE OF UPPER GASTROINTESTINAL BLEEDING. CONCURRENT USE OF AN NSAID OR ASPIRIN MAY POTENTIATE THIS RISK OF BLEEDING. ALTERED ANTICOAGULANT EFFECTS, INCLUDING INCREASED BLEEDING, HAVE BEEN REPORTED WHEN SSRIS AND SNRIS ARE COADMINISTERED WITH WARFARIN.