INTERACTIONS ARE SAME FOR ALL PROTON PUMP INHIBITORS. IT MAY PROLONG ELIMINATION OF DIAZEPAM, PHENYTOIN, AMINOPHYLLINE, AND ANTITRYPSIN. CLARITHROMYCIN INCREASES ITS PLASMA CONCENTRATION BY 30% & MEAN HALF LIFE FROM 1.2 TO 1.6 HRS. IT REDUCES THE ABSORPTION OF KETOCONAZOLE, ITRACOCAZOLE.
PROTON PUMP INHIBITORS POSSIBLY REDUCE PLASMA CONCENTRATION OF ATAZANAVIR -AVOID CONCOMITANT USE.