ARSIKEM® SHOULD BE DILUTED WITH 100 TO 250ML 5% DEXTROSE INJECTION, USP OR 0.9% SODIUM CHLORIDE INJECTION & SHOULD BE ADMINISTERED INTRAVENOUSLY OVER 1-2 HOURS. THE INFUSION DURATION MAY BE EXTENDED UP TO 4 HOURS IF ACUTE VASOMOTOR REACTIONS ARE OBSERVED, AT A DOSE OF 0.15 MG/KG DAILY UNTIL BONE MARROW REMISSION. TOTAL INDUCTION DOSE SHOULD NOT EXCEED 60 DOSES. PATIENT'S ELECTROLYTE, HEMATOLOGIC AND COAGULATION PROFILES SHOULD BE MONITORED AT LEAST TWICE WEEKLY, AND MORE FREQUENTLY FOR CLINICALLY UNSTABLE PATIENTS DURING THE INDUCTION PHASE AND AT LEAST WEEKLY DURING THE CONSOLIDATION PHASE. ECGS SHOULD BE OBTAINED WEEKLY