THE HYPOGLYCEMIC ACTION OF SULFONYLUREAS MAY BE POTENTIATED BY CERTAIN DRUGS INCLUDING NONSTEROIDAL ANTI-INFLAMMATORY AGENTS AND OTHER DRUGS THAT ARE HIGHLY PROTEIN BOUND, SALICYLATES, SULFONAMIDES, CHLORAMPHENICOL, PROBENECID, MONOAMINE OXIDASE INHIBITORS AND BETA ADRENERGIC BLOCKING AGENTS. INTERACTION BETWEEN GLYBURIDE AND FLUOROQUINOLONE ANTIBIOTICS HAS BEEN REPORTED RESULTING IN A POTENTIATION OF THE HYPOGLYCEMIC ACTION OF GLYBURIDE. INTERACTIONS BETWEEN GLYBURIDE AND COUMARIN DERIVATIVES HAVE BEEN REPORTED THAT MAY EITHER POTENTIATE OR WEAKEN THE EFFECTS OF COUMARIN DERIVATIVES. CERTAIN DRUGS TEND TO PRODUCE HYPERGLYCEMIA AND MAY LEAD TO LOSS OF CONTROL. THESE DRUGS INCLUDE THE THIAZIDES AND OTHER DIURETICS, CORTICOSTEROIDS, PHENOTHIAZINES, THYROID PRODUCTS, ESTROGENS, ORAL CONTRACEPTIVES, PHENYTOIN, NICOTINIC ACID, SYMPATHOMIMETICS, CALCIUM CHANNEL BLOCKING DRUGS, AND ISONIAZID. INTERACTION BETWEEN ORAL MICONAZOLE AND ORAL HYPOGLYCEMIC AGENTS LEADING TO SEVERE HYPOGLYCEMIA HAS BEEN REPORTED. WHETHER THIS INTERACTION ALSO OCCURS WITH THE INTRAVENOUS, TOPICAL OR VAGINAL PREPARATIONS OF MICONAZOLE IS NOT KNOWN.