THE RECOMMENDED TOTAL DOSE IS BASED UPON PATIENT WEIGHT, NOT TO EXCEED 100 MG. FOR PATIENTS WEIGHING > 67 KG, THE RECOMMENDED DOSE ADMINISTERED IS 100 MG AS A 15 MG INTRAVENOUS BOLUS, FOLLOWED BY 50 MG INFUSED OVER THE NEXT 30 MINUTES, AND THEN 35 MG INFUSED OVER THE NEXT 60 MINUTES.
FOR PATIENTS WEIGHING = 67 KG, THE RECOMMENDED DOSE IS ADMINISTERED AS A 15 MG INTRAVENOUS BOLUS, FOLLOWED BY 0.75 MG/KG INFUSED OVER THE NEXT 30 MINUTES NOT TO EXCEED 50 MG, AND THEN 0.50 MG/KG OVER THE NEXT 60 MINUTES NOT TO EXCEED 35 MG.
MYOCARDIAL INFARCTION, INITIATED WITHIN 6 - 12 HOURS, 10 MG BY INTRAVENOUS INJECTION, FOLLOWED BY INTRAVENOUS INFUSION OF 50 MG OVER 60 MINUTES, THEN 4 INFUSIONS EACH OF 10 MG OVER 30 MINUTES (TOTAL DOSE 100 MG OVER 3 HOURS; MAX. 1.5 MG/KG IN PATIENTS LESS THAN 65 KG)
PULMONARY EMBOLISM, 10 MG BY INTRAVENOUS INJECTION OVER 1- 2 MINUTES, FOLLOWED BY INTRAVENOUS INFUSION OF 90 MG OVER 2 HOURS; MAX. 1.5 MG/KG IN PATIENTS LESS THAN 65 KG
ACUTE STROKE (TREATMENT MUST BEGIN WITHIN 3 HOURS), BY INTRAVENOUS ADMINISTRATION OVER 60 MINUTES, 900 MICROGRAMS/KG (MAX. 90 MG); INITIAL 10% OF DOSE BY INTRAVENOUS INJECTION, REMAINDER BY INTRAVENOUS INFUSION; ELDERLY OVER 80 YEARS NOT RECOMMENDED