THE USUAL DOSE FOR SQUAMOUS CELL OR TESTICULAR TUMOURS :- 15000 I.U.3 TIMES A WEEK OR 30000 I.U. 2 TIMES A WEEK BY I.M. OR I.V. INJECTION, MAY BE REPEATED AT INTERVALS OF 3-4 WEEKS. TOTAL DOSE :- 500000 I.U. THE DOSE SHOULD BE REDUCED IN PATIENTS OVER 60 YEARS OF AGE.
DOSES FOR MALIGNANT EFFUSION :- 60,000 I.U. IN 100 ML OF 0.9% SOD CHLORIDE MAY BE INSTILLED NTO THE AFFECTED SEROUS CAVITY. TT MAY BE REPEATED IF NECESSARY UP TO A TOTAL CUMULATIVE DOSE OF 500,000 IU DEPENDING ON PT. AGE
LYMPHOMA A DOSE OF 15 000 INTERNATIONAL UNITS ONCE OR TWICE WEEKLY BY INTRAMUSCULAR INJECTION HAS BEEN SUGGESTED, TO A TOTAL DOSE OF 225 000 INTERNATIONAL UNITS. AGAIN, DOSAGE SHOULD BE REDUCED IN OLDER PATIENTS AND IN COMBINATION REGIMENS IF NECESSARY
IN PATIENTS WITH HODGKIN'S DISEASE, ONCE A 50% RESPONSE HAS BEEN ACHIEVED IT MAY BE MAINTAINED WITH 1000 INTERNATIONAL UNITS (1 USP UNIT) OF BLEOMYCIN DAILY, OR 5000 INTERNATIONAL UNITS (5 USP UNITS) WEEKLY
DOSES FOR LYMPHOMAS IN USA :-250 TO 500 I.U. PER KG/BODY WT. ONCE OR TWICE WEEKLY. THE TOTAL DOSE OF BLEOMYCIN IS:- 500000 I.U.