IT IS POSSIBLE THAT DRUGS THAT INHIBIT REPLICATION OF RAPIDLY DIVIDING CELL POPULATIONS SUCH AS BONE MARROW,SPERMATOGONIA AND GERMINAL LAYERS OF SKIN AND GASTROINTESTINAL MUCOSA MAY HAVE ADDITIVE TOXICITY WHEN ADMINISTERED CONCOMITANTLY WITH GANCICLOVIR. THEREFORE, DRUGS SUCH AS DAPSONE, PENTAMIDINE, FLUCYTOSINE, VINCRISTINE, VINBLASTINE, ADRIAMYCIN, AMPHOTERICIN B, TRIMETHOPRIM/SULFAMETHOXAZOLE COMBINATIONS OR OTHER NUCLEOSIDE ANALOGUES, SHOULD BE CONSIDERED FOR CONCOMITANT USE WITH GANCICLOVIR ONLY IF THE POTENTIAL BENEFITS ARE JUDGED TO OUTWEIGH THE RISKS.
GENERALIZED SEIZURES HAVE BEEN REPORTED IN PATIENTS WHO RECEIVED GANCICLOVIR AND IMIPENEM-CILASTATIN. RENAL CLEARANCE OF GANCICLOVIR DECREASED WITH PROBENECID.