COLESTIPOL MAY DELAY OR REDUCE THE ABSORPTION OF CONCOMITANT ORAL MEDICATION SUCH AS PHENYLBUTAZONE, WARFARIN, THIAZIDE, OR PROPRANOLOL, AS WELL AS TETRACYCLINE, PENICILLIN G, PHENOBARBITAL AND THYROID, ESTROGENS, PROGESTRINS & DIGOXIN. IT MAY INTERFERE WITH THE ABSORPTION OF PHOSPHATES, FAT SOLUBLE VITAMINS LIKE A, D, E, & K & PHARMACOKINETICS OF DRUGS THAT UNDERGO ENTEROHEPATIC CIRCULATION. SINCE COLESTIPOL MAY BIND OTHER DRUGS GIVEN CONCURRENTLY, IT IS RECOMMENDED THAT PATIENTS TAKE OTHER DRUGS AT LEAST ONE HOUR BEFORE OR 4 TO 6 HOURS AFTER COLESTIPOL.