CIMETIDINE, FLUOXETINE, FLUVOXAMINE, KETOCONAZOLE, ITRACONAZOLE,ISONIAZID, DEXTROPROPOXYPHENE,DILTIAZEM, ERYTHROMYCIN, CLARITHROMYCIN, REDUCE THE CLEARANCE HENCE DOSE SHOULD BE REDUCED TO ONE THIRD. ALPRAZOLAM ENHANCES ACTION OF IMIPRAMINE,DESIPRAMINE & OTHER ANTIDEPRESSANTS. POTENTIATES ACTION OF ALCOHOL,ANTIPSYCHOTICS, ANTIHISTAMINES, GENERAL ANAESTHETICS, HYPNOTICS, SEDATIVES, OPIOID ANALGESICS AND OTHER CNS DEPRESSANTS. ORAL CONTRACEPTIVES INCREASED ITS PLASMA CONC BY 18%.PRETREATMENT WITH PETHIDINE & MORPHINE DECREASE THE RATE OF ORAL ABSOPTION OF DIAZEPAM.