PEAK PLASMA-ALMOTRIPTAN CONCENTRATIONS ARE OBTAINED IN ABOUT 1 TO 3 HOURS, WITH A BIOAVAILABILITY OF ABOUT 70%. PROTEIN BINDING IS ABOUT 35%. A POTENT SELECTIVE 5-HT 1D RECEPTOR AGONIST. IT PRODUCE A DOSE-RELATED VASOCONSTRICTION IN THE CEREBRAL CIRCULATION. IT DOES NOT BIND TO ALPHA ADRENERGIC, BETA ADRENERGIC, MUSCARINIC, DOPAMINERGIC OR BENZODIAZEPINE RECEPTOR. IT PROVIDES RELIEF IN BOTH THE HEADACHE AND OTHER SYMPTOMS SUCH AS NAUSEA AND PHOTOPHOBIA.