INCREASED CLEARANCE WHEN USED WITH FELBAMATE. ENZYME-INDUCERS E.G. CARBAMAZEPINE, GRISEOFULVIN, PHENOBARBITAL, PHENYTOIN, AND RIFAMPICIN MAY ENHANCE THE CLEARANCE OF GESTODENE. MAY INIHIBIT CICLOSPORIN METABOLISM. HAS KNOWN DRUG INTERACTIONS WITH AMPICILLIN, CHLORAMPHENICOL, CLOMIPRAMINE, GUANETHIDINE, HUMAN INSULIN , IMIPRAMINE, ISONIAZID, METHYL DOPA, NEOMYCIN, NITROFURANTOIN, PHENYLBUTAZONE & PRIMIDONE.