IN CASES OF INADVERTENT OVERDOSE OF FOLIC ACID ANTAGONIST, IT SHOULD BE GIVEN AS SOON AS POSSIBLE, PREFERABLY WITHIN 1 HR. DOSES EQUAL TO OR GREATER THAN THE DOSE OF METHOTREXATE HAVE BEEN RECOMMENDED.
OR
CAN BE GIVEN ORALLY, I.M. OR BY I.V. ROUTE. IT CAN BE GIVEN BY I.V.INFUSION IN A DOSE EQUIVALENT TO 75 MG OF FOLINIC ACID WITHIN 12 HRS.FOLLOWED BY 12 MG I.M. EVERY 6 HRS FOR 4 DOSES.
TO ENHANCE THE CYTOTOXIC EFFECT OF FLUOROURACIL IN ADVANCED COLORECTAL CANCER:
FOLINIC ACID 200 MG PER SQ.M BODY-SURFACE BY SLOW IV INJECTION OVER AT LEAST 3 TO 5 MINUTES FOLLOWED BY FLUOROURACIL AT AN INITIAL DOSE OF 370 MG PER 1 INTRAVENOUSLY: THE TREATMENT IS GIVEN DAILY FOR 5 CONSECUTIVE DAYS AND MAY BE REPEATED AT INTERVALS OF 21 TO 28 DAYS. LOWER DOSES OF FOLINIC ACID (20 MG PER NR BY IV INJECTION FOLLOWED BY FLUOROURACIL 425 MG PER NR) HAVE ALSO BEEN USED.
FOLATE-DEFICIENT MEGALOBLASTIC ANAEMIA: DOSES OF 15 MG DAILY BY MOUTH HAVE BEEN SUGGESTED. IF GIVEN INTRAMUSCULARLY A DOSE OF UP TO I MG DAILY HAS BEEN RECOMMENDED. IT IS UNSUITABLE FOR MEGALOBLASTIC ANAEMIA SECONDARY TO VITAMIN-B12 DEFICIENCIES.