INDICATED FOR THE TREATMENT OF EXTRAVASATION RESULTING FROM IV ANTHRACYCLINE CHEMOTHERAPY.
SHOULD BE GIVEN ONCE DAILY FOR 3 CONSECUTIVE DAYS. THE FIRST INFUSION SHOULD BE INITIATED AS SOON AS POSSIBLE AND WITHIN THE FIRST SIX HOURS AFTER EXTRAVASATION. GIVEN BY IV INFUSION, 1 G/SQ.M OF BODY SURFACE (MAX. 2 G) ON DAY 1 AND 2, THEN 500 MG/ SQ.M ON DAY 3
DOSE SHOULD BE REDUCED BY 50% IN PATIENTS WITH CREATININE CLEARANCE VALUES < 40 ML/MIN.
ADMINISTERED AS AN INTRAVENOUS INFUSION OVER 1 TO 2 HOURS IN A LARGE CALIBER VEIN IN AN EXTREMITY/AREA OTHER THAN THE ONE AFFECTED BY THE EXTRAVASATION. COOLING PROCEDURES SUCH AS ICE PACKS, IF USED, SHOULD BE REMOVED FROM THE AREA AT LEAST 15 MINUTES BEFORE TOTECTβ’ ADMINISTRATION IN ORDER TO ALLOW SUFFICIENT BLOOD FLOW TO THE AREA OF EXTRAVASATION. TREATMENT ON DAY 2 AND DAY 3 SHOULD START AT THE SAME HOUR (+/- 3 HOURS) AS ON THE FIRST DAY.