DO NOT INITIATE AVASTIN UNTIL AT LEAST 28 DAYS FOLLOWING MAJOR SURGERY. THE SURGICAL INCISION SHOULD BE FULLY HEALED PRIOR TO INITIATION OF AVASTIN.
A DOSE OF 5 MG/KG ONCE EVERY 14 DAYS IS GIVEN IN A SOLUTION OF 100 ML OF SODIUM CHLORIDE 0.9%. THE FIRST DOSE SHOULD BE GIVEN AS AN INTRAVENOUS INFUSION OVER 90 MINUTES; IF THIS IS WELL TOLERATED THE SECOND DOSE SHOULD BE GIVEN OVER 60 MINUTES, AND IF THIS IS WELL TOLERATED THEN SUBSEQUENT DOSES MAY BE GIVEN OVER 30 MINUTES.
METASTATIC CARCINOMA OF THE COLON OR RECTUM:
BEVACIZUMAB, USED IN COMBINATION WITH INTRAVENOUS 5-FU-BASED CHEMOTHERAPY, IS ADMINISTERED AS AN INTRAVENOUS INFUSION (5 MG/KG OR 10 MG/KG) EVERY 1 4 DAYS.
THE RECOMMENDED DOSE OF BEVACIZUMAB, WHEN USED IN COMBINATION WITH BOLUS-IFL, IS 5 MG/KG.
THE RECOMMENDED DOSE OF BEVACIZUMAB, WHEN USED IN COMBINATION WITH FOLFOX4, IS 10 MG/KG.
NON-SQUAMOUS, NON-SMALL CELL LUNG CANCER:
THE RECOMMENDED DOSE OF BEVACIZUMAB IS 15 MG/KG, AS AN IV INFUSION EVERY 3 WEEKS.
METASTATIC BREAST CANCER:
THE RECOMMENDED DOSE OF BEVACIZUMAB IS 10 MG/KG, AS AN IV INFUSION EVERY 14 DAYS.