AMINOGLYCOSIDE ANTIBIOTICS MAY ENHANCE THE RISK OF DEAFNESS, POTENTIATES ANTI-HYPERTENSIVES. CAUSES LITIHUM TOXICITY IN THOSE RECEIVING BOTH DRUGS. WITH CO-TRIMOXAZOLE PRODUCES THROMBOCYTOPENIA. NSAIDS DIMINISH THE DIURETIC EFFECTS.
ANTIHYPERTENSIVE EFFECTS OF IT MAY BE ANTAGONISED BY DRUGS THAT CAUSE FLUID RETENTION, SUCH AS CORTICOSTEROIDS, NSAIDS, OR CARBENOXOLONE. POSTURAL HYPOTENSION ASSOCIATED WITH DIURETIC THERAPY MAY BE ENHANCED BY CONCOMITANT INGESTION OF ALCOHOL, BARBITURATES, OR OPIOID ANALGESIC. IN SOME PATIENTS, THE ADMINISTRATION OF A NON-STEROIDAL ANTI-INFLAMMATORY AGENT CAN REDUCE THE DIURETIC, NATRIURETIC, AND ANTIHYPERTENSIVE EFFECTS OF LOOP, POTASSIUM-SPARING AND THIAZIDE DIURETICS. THEREFORE, THE PATIENT SHOULD BE OBSERVED CLOSELY TO DETERMINE IF THE DESIRED EFFECT OF THE DIURETIC IS OBTAINED.