AVONEX (BIOGEN) IS GIVEN IN A DOSE OF 6 MILLION UNITS (30 MICROGRAMS) ONCE WEEKLY BY INTRAMUSCULAR INJECTION.
REBIF (SERONO) IS GIVEN IN AN ESCALATING DOSE OVER 4 WEEKS, TO 12 MILLION UNITS (44 MICROGRAMS) THREE TIMES WEEKLY BY SUBCUTANEOUS INJECTION, OR TO 6 MILLION UNITS (22 MICROGRAMS) THREE TIMES WEEKLY BY SUBCUTANEOUS INJECTION IN PATIENTS UNABLE TO TOLERATE THE HIGHER DOSE.
AVONEX IS ALSO INDICATED FOR THE TREATMENT OF PATIENTS WHO HAVE HAD A SINGLE DEMYELINATING EVENT WITH AN ACTIVE INFLAMMATORY PROCESS IF IT IS SUFFICIENTLY SEVERE TO WARRANT INTRAVENOUS CORTICOSTEROIDS.
INTERFERON BETA-1B IS GIVEN IN BOTH RELAPSING-REMITTING AND IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS IN A DOSE OF 8 MILLION UNITS (250 MICROGRAMS) ON ALTERNATE DAYS BY SUBCUTANEOUS INJECTION.