EXACERBATION OR THE INITIAL PRESENTATION OF A NUMBER OF AUTOIMMUNE AND INFLAMMATORY DISORDERS HAS BEEN OBSERVED FOLLOWING CONCURRENT USE OF INTERFERON-ALFA AND PROLEUKIN, INCLUDING CRESCENTIC IGA GLOMERULONEPHRITIS, OCULO-BULBAR MYASTHENIA GRAVIS, INFLAMMATORY ARTHRITIS, THYROIDITIS, BULLOUS PEMPHIGOID, AND STEVENS-JOHNSON SYNDROME,EXACERBATION OF CROHN'S DISEASE, SCLERODERMA, DIABETES MELLITUS, CHOLECYSTITIS & CEREBRAL VASCULITIS.