IMIGLUCERASE IS GIVEN BY INTRAVENOUS INFUSION OVER 1 TO 2 HOURS FOR THE TREATMENT OF TYPE 1 OR TYPE 3 GAUCHER DISEASE. ALTERNATIVELY, THE DOSE MAY BE INFUSED AT A RATE NOT EXCEEDING 1 UNIT/KG PER MINUTE. THE DOSAGE DEPENDS ON THE SEVERITY OF SYMPTOMS, AND INITIAL DOSES CAN VARY FROM 2.5 UNITS/KG THREE TIMES WEEKLY TO 60 UNITS/KG ONCE EVERY TWO WEEKS. FURTHER INCREASES OR DECREASES IN DOSES ARE MADE ACCORDING TO INDIVIDUAL RESPONSE. ONCE THE PATIENT'S CONDITION IS STABILISED, MONITORING AND DOSAGE ADJUSTMENT UP OR DOWN IS CARRIED OUT AT USUAL INTERVALS OF 6 TO 12 MONTHS. IN THE UK, THE BRITISH NATIONAL FORMULARY COUNCIL NOTES THAT HIGHER DOSES OF 120 UNITS/KG INFUSED OVER 1 TO 2 HOURS ARE GIVEN ONCE EVERY 2 WEEKS FOR TYPE 3 GAUCHER DISEASE.