DIRECT RENIN INHIBITOR, DECREASING PLASMA RENIN ACTIVITY AND INHIBITING CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN I.
ALL AGENTS THAT INHIBIT THE RENIN-ANGIOTENSIN SYSTEM SUPPRESS THE NEGATIVE FEEDBACK LOOP, LEADING TO A COMPENSATORY RISE IN PLASMA RENIN CONCENTRATION. ALISKIREN BLOCKS THE CLINICAL EFFECT OF INCREASED RENIN LEVELS.