BINDS TO AND ACTIVATES ALL KNOWN INTRACELLULAR RETINOID RECEPTOR SUBSTRATES. ONCE ACTIVATED, THESE RECEPTORS FUNCTION AS TRANSCRIPTION FACTORS THAT REGULATE THE EXPRESSION OF GENES THAT CONTROL THE PROCESS OF CELLULAR DIFFERENTIATION AND PROLIFERATION OF BOTH NORMAL AND NEOPLASTIC CELLS.
DO NOT USE GEL ON PATIENT WHO REQUIRES SYSTEMIC ANTI-KS THERAPY (EG, MORE THAN 10 NEW KS LESIONS IN PRIOR MONTH, SYMPTOMATIC PULMONARY KS, SYMPTOMATIC VISCERAL INVOLVEMENT).