CONCURRENT USE OF LEVO-DROMORAN WITH ALL CENTRAL NERVOUS SYSTEM DEPRESSANTS (EG, ALCOHOL, SEDATIVES, HYPNOTICS, OTHER OPIOIDS, GENERAL ANESTHETICS, BARBITU-RATES, TRICYCLIC ANTIDEPRESSANTS, PHENOTHIAZINES, TRANQUILIZERS, SKELETAL MUSCLE RELAXANTS AND ANTIHISTAMINES) MAY RESULT IN ADDITIVE CENTRAL NERVOUS SYSTEM DEPRESSANT EFFECTS. RESPIRATORY DEPRESSION, HYPOTENSION, AND PROFOUND SEDATION OR COMA MAY OCCUR. WHEN SUCH COMBINED THERAPY IS CONTEMPLATED, THE DOSE OF ONE OR BOTH AGENTS SHOULD BE REDUCED. AGONIST/ANTAGONIST ANALGESICS (EG, PENTAZOCINE, NALBUPHINE, BUTORPHANOL, DEZOCINE AND BUPRENORPHINE) SHOULD NOT BE ADMINISTERED TO A PATIENT WHO HAS RECEIVED OR IS RECEIVING A COURSE OF THERAPY WITH A PURE AGONIST OPIOID ANALGESIC SUCH AS LEVO-DROMORAN.